The usual effective dosage range is 5 to 20 mg per day administered as a single daily dose. Older patients, on average, have (approximately doubled) higher blood levels and area underneath the plasma concentration time curve (AUC) than younger patients. The once daily dosing for the treatment of congestive heart failure was the only real dosage regimen used during clinical trial development and was determined through the measurement of hemodynamic responses. Dermatologic unwanted effects have included rare cases of urticaria, alopecia, herpes zoster, photosensitivity, wounds, skin disease, pemphigus, erythema, psoriasis, and rare cases of other severe skin reactions, including toxic epidermal necrolysis and Stevens-Johnson Syndrome, (causal relationship hasn't been established).
The diuretic should be discontinued, when possible, for 2 to three days before beginning therapy with Prinivil to lessen the likelihood of hypotension. After six events of Lisinopril therapy, a 74-year-old patient reported penile "swelling". Carcinogenesis, Mutagenesis, Impairment of Fertility. Similar considerations may connect with patients with ischemic heart or cerebrovascular disease, or perhaps patients with acute myocardial infarction, in whom an excessive fall in blood pressure levels could result in a myocardial infarction or cerebrovascular accident.